Brefeldin A
Intracellular transport inhibitor / Specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Activates sphingomyelin metabolism. Cell permeable.
Biochemicals & reagents
20350-15-6
Fermentation product from Penicillium brefeldianum
1) Fujiwara et al. (1988) Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum,; J. Biol. Chem., 263 18545 / 2) Shao et al. (1996), Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53; Exp. Cell Res., 227 190 / 3) Linardic et al. (1996), Brefeldin A promotes hydrolysis of sphingomyelin; Cell Growth Differ. 7 765
-20°C
TARGET: ER/Golgi; UPR (Unfolded Protein Response) -- PATHWAY: Intracellular transport; Apoptosis inducer; Lipid signaling; Sphingolipid metabolism; NFkappaB; Autophagy -- RESEARCH AREA: Cell death