Aspterric acid
Plant growth regulator / Aspterric acid is a fungal sequeterpenoid1 plant growth inhibitor discovered using a resistance-gene-directed approach.1 It is an inhibitor of dihydroxy-acid dehydratase (DHAD, IC50=0.31 and 0.5 uM for AteDHAD and AthDHAD respectively), an enzyme in the branched-chain amino acid biosynthetic pathway in plants and is an effective herbicide in spray applications. It has no significant cytotoxicity in human cell lines (up to 500 uM).2 Inhibits the development of pollen in Arabidopsis thalania.3
Biochemicals & reagents
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1) Tsuda et al. (1978), Aspterric acid, a new sesquiterpenoid of the carotene group, a metabolite from Aspergillus terreus IFO-6123. X-Ray crystal and molecular structure of its p-bromobenzoate; J. Chem. Soc. Chem. Commun., 4 161 2) Yan et al. (2018), Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action; Nature., 559 415 3) Shimada et al. (2002), Aspterric acid and 6-hydroxymellein, inhibitors of pollen development in Arabidopsis thaliana, produced by Aspergillus terreus; Z. Naturforsch. C, 57 459
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