Phenylacetyl-L-glutamine
Bioactive gut microbial metabolite / A microbial-mammalian host co-metabolite which increases with age1 and especially in extreme longevity2. Gut-microbiota-dependent PAG is associated with cardiovascular disease pathogenesis3 via action at adrenergic receptors4. Plasma PAG levels may be a valuable indicator for predicting coronary in-stent restenosis.5
Biochemicals & reagents
28047-15-6
N-Phenylacetylglutamine; Phenylacetylglutamine; PhenylAc-Gln-OH; NSC-203800; PAG
1 Swann et al. (2013) Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations; J. Proteome Res. 12 3166 2 Collino et al. (2013) Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism; PLoS One 8 1 3 Romano et al. (2022) Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure; Circ. Heart Fail. Dec 16 e009972 online ahead of print 4 Nemet et al. (2020) A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors; Cell 180 862 5 Yua et al. (2022) Prognostic value of plasma phenylalanine and gut microbiota-derived metabolite phenylacetylglutamine in coronary in-stent restenosis; Front. Cardiovasc. Med. 9 944155
-20°C
DISEASE AREA: Kidney disease; Heart disease