PF-9366
Supplier:
Catalogue number:
10-4635-02
Size:
25 mg
Product is available in:
Methionine adenosyltransferase 2A inhibitor / PF-9366 is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1 It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 µM and 225 nM respectively.
Product Type:
Biochemicals & reagents
CAS Number:
72882-78-1
Reference:
1) Quinlan et al. (2017), Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol., 13 785
Storage Temperature:
-20°C
Additional Information:
DISEASE AREA: Cancer