Dantrolene Na
SR calcium release inhibitor / Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons.2 Displays neuroprotective effects.3 Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.4
Biochemicals & reagents
14663-23-1
1) Zhao et al. (2001), Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem., 276 13810 2) Frandsen and Schousboe (1992), Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspasrtate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA, 89 2590 3) Muehlschlegel and Sims (2009), Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care, 10 103 4) Lu et al. (2014), A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA, 111 E5292
RT
PATHWAY: Calcium signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration