Rottlerin
PKCδ inhibitor / Reported to inhibit PKCδ selectively however this result has been called into question1. Displays neuroprotective effects2. Induces autophagy3. Cell permeable.
Biochemicals & reagents
82-08-6
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 2) Zhang et al. (2007), Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson’s disease; J. Pharmacol. Exp. Ther., 322 913 3) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PLoS One, 4 e7124
RT
PATHWAY: Autophagy -- RESEARCH AREA: Cell death; Neuroscience -- DISEASE AREA: Neurodegeneration