SIN-1
Peroxynitrite donor / A metabolite of mosidomine1 which spontaneously releases nitric oxide and superoxide anion which react to form peroxynitrite under physiological conditions.2 The presence of HEPES leads to the formation of hydrogen peroxide and while its absence leads to the formation of peroxynitrite.3 Inhibits platelet aggregation.4 Inhibits aggregation and toxicity of amyloid- in cellular assays.5
Biochemicals & reagents
16142-27-1
3-Morpholinylsydnonimine chloride
1) Nishikawa et al. (1982) Inhibition of platelet aggregation and stimulation of guanylte cyclase by an antianginal agent molsidomine and its metabolites; J. Pharmacol. Exp. Ther. 220 183 2) Hogg et al. (1992) Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J. 281 419 3) Kirsch et al. (1998) Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism. J. Biol. Chem. 273 12716 4) Priora et al. (2011) In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res. 64 289 5) Ren et al. (2017) Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-? Aggregation Inhibitor; ACS Omega. 2 243
-20°C
PATHWAY: Redox; Coagulation -- RESEARCH AREA: Oxidative stress; Neuroscience -- DISEASE AREA: Neurodegeneration