PBD-150
Supplier:
Catalogue number:
10-4885-01
Size:
10 mg
Product is available in:
Human glutaminyl cyclase inhibitor / Inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2
Product Type:
Biochemicals & reagents
CAS Number:
790663-33-1
Reference:
Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; J. Med. Chem., 49 664 Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Nat. Med., 14 1106
Storage Temperature:
-20°C
Additional Information:
PATHWAY: Posttranslational modification -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration