Ophiobolin
Supplier:
Catalogue number:
10-3150-01
Size:
200 µg
Product is available in:
Autophagy inducer / Anticancer / Selectively inhibits the growth of cancer cells (IC50=0.4-4.3 uM) over normal cells (IC50=20.9 uM).1 Induces non-apoptotic cell death in glioblastoma cells and is active in an in vivo model.2 Covalently reacts with primary amines such as lysine side chains2 and phosphatidylethanolamine3 forming unique pyrrole adducts. Induces ER stress4, paraptosis4 and autophagy5.
Product Type:
Biochemicals & reagents
CAS Number:
4611-05-6
Alternative Names:
Cochliobolin A; Ophiobalin; NSC 114340
Additional Information:
PATHWAY: Paraptosis; Autophagy; Fatty acid metabolism; Mitochondrial function -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Cancer