icFSP1
Ferroptosis suppressor protein (FSP1) inhibitor / Ferroptosis suppressor protein-1 (FSP1) along with ubiquinone and NAD(P)H/H+ has been identified as a second ferroptosis suppressing system which prevents lipid peroxidation independently of the cysteine-glutathione-glutathione peroxidase 4 (GPX4) axis.1-3 icFSP1 (1115910-36-5) was discovered in a screen to identify inhibitors of FSP1. However, it does not competitively inhibit FSP1 enzyme activity but triggers subcellular relocalization of FSP1 (at 2.5 µM) from the membrane and FSP1 condensation before ferroptosis induction. icFSP1-induced FSP1 condensates show droplet-like properties consistent with phase separation. icFSP1-impairs tumor growth and induces FSP1 condensates in tumors in vivo.4
Biochemicals & reagents
1115910-36-5
1 Bersuker et al. (2019), The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis; Nature, 575 688 2 Doll et al. (2019), FSP1 is a glutathione-independent ferroptosis suppressor; Nature, 575 693 3 Mishima et al. (2022), A non-canonical vitamin K cycle is a potent ferroptosis suppressor; Nature, 608 778 4 Nakamura et al. (2023), Phase separation of FSP1 promotes ferroptosis; Nature, 619 371
-20°C
PATHWAY: Ferroptosis -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer