Ferrostatin-1
Ferroptosis inhibitor / Inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death1. Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices1. Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells2. Inhibits oxidative lipid damage and cell death in diverse disease models3. Prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.
Biochemicals & reagents
347174-05-4
1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060 2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732 3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551 4) Nowak et al. (2013), Protein kinase C-a interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764
RT
PATHWAY: Ferroptosis; Apoptosis inhibitor -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer