Amifostine
Cellular protectant / Broad sprectrun radio- and chemoprotective agent. Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.
Biochemicals & reagents
20537-88-6
WR-2721
1) Capizzi et al. (2000), Chemoprotective and radioprotective effects of amifostine: an update of clinical trials; Int. J. Hematol., 72 425 / 2) Provinciali et al. (1999), In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients; Life Sci., 64 1525 / Koukourakis et al. (2004), Amifostine before chemotherapy: improved tolerance profile of the subcutaneous over the intravenous route.; Cancer Chemother. Pharmacol., 53 8 / 4) Mauri restores transcriptional activity of specific p53 mutant proteins in a yeast functional assayci et al. (2001), Amifostine (WR2721; Oncogene, 20 3533
RT
PATHWAY: Apoptosis inhibitor; Redox; DNA repair; p53 -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer