Maintains stem cells in pluripotent state / Extends the pluripotency of hematopoietic stem cells (IC50 = 127 nM) by antagonizing AhR signaling resulting in continued expression of CD34. Effects are easily reversed by the removal of the SR1.
Product Type:
Biochemicals & reagents
CAS Number:
1227633-49-9
Alternative Names:
Stemregenin 1
Reference:
1) Boitano et al. (2010), Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science, 329 1354
Storage Temperature:
-20°C
Additional Information:
TARGET: Transcription factor -- PATHWAY: Transcription -- RESEARCH AREA: Stem cells