Indoximod
IDO modulator / tryptophan mimetic / Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
Biochemicals & reagents
110117-83-4
1) Hou et al. (2007), Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses; Cancer Res. 67 792 2) Soliman et al. (2010), Indoleamine 2,3-dioxygenase: is it an immune suppressor?; Cancer J. 16 354 3) Friberg et al. (2002), Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T-cell mediated rejection; Int.J.Cancer 101 151 4) Metz et al. (2012), IDO inhibits a tryptophan sufficiency signal that stimulates mTOR; Oncoimmunol. 1 1460
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TARGET: Tryptophan -- PATHWAY: Amino acid metabolism; mTOR; Amino acid metabolism; IDO/TDO pathways -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer