HIF-2α-I2
HIF-2α antagonist / Potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2
Biochemicals & reagents
1422955-31-4
TC-S 7009
1) Scheuermann et al. (2013), Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol., 9 271 2) Masetti et al. (2014), Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One, 9(4) e94986 3) Rodgers et al. (2013), Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem., 56 1739
-20°C
TARGET: Transcription factor -- PATHWAY: Redox; Transcription -- RESEARCH AREA: Oxidative stress