SLU-PP-332
pan-ERR agonist/Exercise mimetic / Pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM) with highest potency for ERRα.1,2 SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line.2 It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.2
Biochemicals & reagents
303760-60-3
4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide; SR9861
1) Lin et al. (2018), Design, synthesis, and evaluation of simple phenol amides as ERR? agonists; Bioorg.Med.Chem.Lett., 28 1313 2) Billon et al. (2023), Synthetic ERR?/ß/? Agonist Induces an ERR?-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity; ACS Chem. Biol., 18 756
-20°C
TARGET: Transcription factor -- PATHWAY: Mitochondrial function; Estrogen; Transcription -- RESEARCH AREA: Exercise