Daminozide
Supplier:
Catalogue number:
10-1403-02
Size:
250 mg
Product is available in:
KDM2/7 demethylase inhibitor / A selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 μM1.
Product Type:
Biochemicals & reagents
CAS Number:
1596-84-5
Alternative Names:
N-(Dimethylamino)succinamic acid
Reference:
1) Rose et al. (2012), Plant growth regulator daminozide is a selective inhibitor of hman KDM2/7 histone methylases; J. Med. Chem., 55 6639
Storage Temperature:
RT
Additional Information:
TARGET: Protein demethylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics