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GSK-J4

Supplier:
Catalogue number:
10-1394-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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JMJ H3K27 Demethylase inhibitor (Cell Permeable) / Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.

Product Type:

Biochemicals & reagents

CAS Number:

1373423-53-0

Reference:

1) Kruidenier et al. (2012), Selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response; Nature, 488 404 2) Inoue et al. (2014) New Braf knockin mice provide a pathogenic mechanism of developmental defects and therapeutic approach in cardio-facio-cutaneous syndrome; Hum. Mol. Genet., July 17, Epub ahead of print

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein demethylase -- PATHWAY: Chromatin; Cytokine; Posttranslational modification -- RESEARCH AREA: Epigenetics; Immunology -- DISEASE AREA: Inflammation