IOX 1
Supplier:
Catalogue number:
10-1426-02
Size:
25 mg
Product is available in:
JMJD demethylase inhibitor / Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling1. Cell permeable
Product Type:
Biochemicals & reagents
CAS Number:
5852-78-8
Alternative Names:
5-Carboxy-8HQ
Reference:
1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535
Storage Temperature:
RT
Additional Information:
TARGET: Protein demethylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics; Oxidative stress