Pepstatin A
Aspartic protease inhibitor / Selective inhibitor of aspartyl proteases.1 Inhibits human pepsin, human gastricsin, renin, cathepsin D and E and bovine chymosin.2 Does not inhibit thiol proteases, neutral proteases or serine proteases.3 It suppresses RANKL-induced osteoclast differentiation.4
Biochemicals & reagents
26305-03-3
1) Merck Index 14:7147 2) Marciniszyn et al. (1976) Mode of inhibition of acid proteases by pepstatin J.Biol.Chem. 251 7088 3) Oda (2012) New families of carboxy peptidases: serine-carboxyl peptidases and glutamic peptidases. J.Biochem. 151 13 4) Yoshida et al. (2006) Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation J.Biochem. 139 583
-20°C
TARGET: Protease -- PATHWAY: Degradation