Benzamidine HCl
Trypsin and serine protease inhibitor / Reversible inhibitor of trypsin and trypsin-like enzymes and other serine proteases.1-3 Concentration used for general protease inhibition is 1 mM. Also a competitive inhibitor of thrombin and plasmin. May be added to blood samples to prevent proteolytic degradation of various peptide analytes such as glucagon4 and TRH5.
Biochemicals & reagents
1670-14-0
1) Markwardt et al. (1968) Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamide; Eur. J. Biochem., 6 502 2) Deutscher et al. (1990), Maintaining protein stability; Methods Enzymol., 182 83 3) Jaswinski et al. (1990), Preparations of extracts from yeast; Methods Enzymol., 182 154 4) Ensinck et al. (1972), Use of Benamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma; J. Clin. Endocrinol. Metab., 35 463 5) Jeffcoate et al. (1974), Use of benzamide to prevent the destruction of thyrotropin-release hormone (TRH) by blood; Endocrinol. Metab, 38 155
RT
TARGET: Protease -- PATHWAY: Coagulation; Degradation