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PD-150606

Supplier:
Catalogue number:
10-1515-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Calpain inhibitor / A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3.

Product Type:

Biochemicals & reagents

CAS Number:

179528-45-1

Reference:

1) Wang et al. (1996), An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA, 93 6687 2) Waters et al. (1997), Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap., 283 1177 3) Ali et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun., 423 1

Storage Temperature:

-20°C

Additional Information:

TARGET: Protease -- RESEARCH AREA: Oxidative stress; Neuroscience