Rolipram
PDE4 inhibitor / Selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 µM. Displays beneficial effects in neurodegenerative diseases. Displays anti-inflammatory activity and synergizes with forskolin. Cell permeable.
Biochemicals & reagents
61413-54-5
ZK 62711
1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase ; Biochem. J., 241 535 / 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum ; J. Neurosci., 28 10460 / 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837
RT
TARGET: PDE (Phosphodiesterase) -- PATHWAY: cAMP / cGMP signaling; Autophagy -- RESEARCH AREA: Neuroscience; Cell death -- DISEASE AREA: Neurodegeneration; Inflammation