Vinpocetine
PDE1 inhibitor / Phosphodiesterase PDE1 inhibitor (IC50=21 μM)1. Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity2. It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus3. Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury4. Exerts neuroprotective effects by suppressing microglial inflammation5.
Biochemicals & reagents
42971-09-5
1) Hagiwara et al. (1984), Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol., 33 453 2) Molnar and Erdo (1995), Vinpocetine is as potent as phrnytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol., 273 303 3) Gomez et al. (2014), The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem., 130 770 4) Wang et al. (2014), Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett., 566 247 5) Zhao et al. (2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol., 7 187
RT
TARGET: PDE (Phosphodiesterase) -- PATHWAY: Cytokine; cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; IschemiaNeurodegeneration