BC-11-38
Supplier:
Catalogue number:
10-1408-02
Size:
25 mg
Product is available in:
PDE11 inhibitor / A potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 μM).1 IC50s for PDE1-10 are greater than 100 μM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2
Product Type:
Biochemicals & reagents
CAS Number:
686770-80-9
Reference:
1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155 2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223
Storage Temperature:
RT
Additional Information:
TARGET: PDE (Phosphodiesterase) -- PATHWAY: cAMP / cGMP signaling