Cilostamide
PDE3 inhibitor / Selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B3. Reverses the effect of leptin on food intake and body weight4.
Biochemicals & reagents
68550-75-4
OPC-3689
1) Hidaka et al. (1979), Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation; J. Pharmacol. Exp. Ther., 211 26 2) Christensen and Torphy et al. (1994), Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents; Annu. Rep. Med. Chem., 29 185 3) Ahmad et al. (2000), cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells; J. Immunol., 164 4678 4) Zhao et al. (2002), A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding; Nat. Neuroscience, 5 727
RT
TARGET: PDE (Phosphodiesterase) -- PATHWAY: AKT; cAMP / cGMP signaling -- DISEASE AREA: Obesity; Diabetes