Eniluracil
Dihydropyrimidine dehydrogenase inhibitor / Eniluracil is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1,2,3 DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.
Biochemicals & reagents
59989-18-3
GW776C85
1) Porter et al. (1992), Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J.Biol.Chem. 267 5236 2) Baccalnari et al. (1993), 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc.Natl.Acad.Sci.USA 90 11064 3) Schilsky and Kindler (2000) Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin.Investig.Drugs 9 1635
-20°C
TARGET: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH); DNA -- PATHWAY: DNA damage -- DISEASE AREA: Cancer