RG-108
DNA Methyltransferase inhibitor / A non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. Enhances the reversion of neural progenitor cells to the pluripotent state3.
Biochemicals & reagents
48208-26-0
N-Phthalyl-L-tryptophan
1) Brueckner et al. (2005), Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferase; Cancer Res., 65 6305 2) Stresemann et al. (2006), Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines; Cancer Res., 66 2794 3) Szablowska-Gadomska et al. (2012), Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood; Acta Neurobiol. Exp., 72 337
RT
TARGET: DNA methylation; DNA -- PATHWAY: Chromatin; DNA damage -- RESEARCH AREA: Epigenetics; Stem cells; Neuroscience -- DISEASE AREA: Cancer