Decitabine
DNA hypomethylation agent / Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.
Biochemicals & reagents
2353-33-5
NSC-127716
1) Bender et al. (1998), Inhibition of DNA methylation by 5-aza-2’-deoxycytidine suppresses the growth of human tumor cell lines; Cancer Res., 58 95 / 2) El-Serafi et al. (2011), Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A; Differentiation, 81 35
-20°C
TARGET: DNA methylation; DNA -- PATHWAY: Chromatin; DNA damage -- RESEARCH AREA: Epigenetics; Stem cells -- DISEASE AREA: Cancer