Remodelin
Acetyl-transferase NAT10 inhibitor / Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones.1 Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells1, normalizing progeric and aging cells2. Enhances health span in a mouse model of human accelerated aging syndrome.3 Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A.4 Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.5
Biochemicals & reagents
949912-58-7
1) Larrieu et al. (2014), Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science, 344 527 2) Larrieu et al. (2018), Inhibition of the Acetyltransferase NAT10 Normalizaes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal., 11 eaar5401 3) Balmus et al. (2018), Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nature Commun., 9 1700 4) Cobb et al. (2016), Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell, 15 1039 5) Ma et al. (2016), Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res., 8 4215
-20°C
TARGET: Acetyltransferase; Cytoskeleton -- PATHWAY: Chromatin; Posttranslational modification; Nuclear transport -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Ageing