Mycalolide B
Actin depolymerizing agent / A novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1 It selectively and completely depolymerizes F-actin to G-actin via a novel mechanism different from that of the cytochalasin D.2 It is a novel and specific inhibitor of actomyosin ATPase.3
Biochemicals & reagents
122752-21-0
1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710 2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614 3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151
-20°C
TARGET: ATPase; Cytoskeleton