NSC66811
Supplier:
Catalogue number:
10-1334-02
Size:
50 mg
Product is available in:
p53/mdm2 inhibitor / A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
Product Type:
Biochemicals & reagents
CAS Number:
6964-62-1
Reference:
1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759
Storage Temperature:
RT
Additional Information:
TARGET: Transcription factor; Cytochrome/MDR -- PATHWAY: p53; Transcription -- DISEASE AREA: Cancer