Mitoquinone mesylate
Mitochondria-targeted antioxidant / A mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2,3 Protects pancreatic -cells against oxidative stress and improves insulin secretion.4 Inhibits respiratory syncytial virus (RSV) production via lowering of mitochondrial ROS levels.5 Cell permeable.
Biochemicals & reagents
845959-50-4
MitoQ
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model; Free Radic. Biol. Med., 49 1674 2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease; J. Neurosci., 31 15703 3) Young and Franklin, (2019), The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice; Mol. Cell Neurosci. 101 103409 4) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic ?-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873 5) MengJie et al. (2019), Subversion of Host Cell Mitochondria by RSV to Favor Virus Production in Dependent on Inhibition of Mitochondrial Complex I and ROS Generation; Cells 8 1417
-20°C
TARGET: Telomerase; Antioxidant -- PATHWAY: Mitochondrial function; Redox; Ferroptosis -- RESEARCH AREA: Neuroscience; Oxidative stress; Cell death -- DISEASE AREA: Neurodegeneration; CancerDiabetes; Heart disease