SOD mimetic / Superoxide dismutase (SOD) mimetic. Displays protective effects in CNS1 kidney2 and radiation damage3. Inhibits superoxide anion-induced inflammatory pain in mice.4 Blunts diabetes-induced upregulation of NADPH oxidase and ER stress in a rat model of diabetic nephropathy.5 Cell permeable
Biochemicals & reagents
2226-96-2
4-Hydroxy TEMPO
1) Lipman et al. (2006), Neuroprotective effects if the stable nitroxide compound Tempol in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells; Eur. J. Pharmacol., 549 50 2) Guron et al. (2006), Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats; J. Hypertens., 24 387 3) Samuni and Barenholz (1997), Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides; Free Radic. Biol. Med., 23 972 4) Bernardy et al. (2017), Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice; Biomed. Res. Int., 2017 9584819 5) De Blasio et al. (2017), The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy; Eur. J. Pharmacol., 807 12
-20°C
TARGET: SOD (superoxide dismutase); Antioxidant -- PATHWAY: NAD, NADP pathways; Coagulation; Cytokine -- RESEARCH AREA: Cellular stress; Oxidative stress; Neuroscience -- DISEASE AREA: Diabetes; Kidney diseaseInflammation