Lorcainide HCl
Voltage-gated sodium channel blocker / Voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3
Biochemicals & reagents
58934-46-6
1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748 2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554 3) Almotrefi et al. (1999), class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866
-20°C
TARGET: Ion channel; ATPase -- PATHWAY: Sodium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Heart disease