Dihydroresveratrol
Resveratrol metabolite / Metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4 Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5 Inactive analog of resveratrol in induction of premature senescence.6
Biochemicals & reagents
58436-28-5
1) Jung et al. (2009), Interaction of dietary resveratrol with animal-associated bacteria; FEMS Microbiol. Lett., 297 266 2) Bode et al. (2013), In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota; Am. J. Clin. Nutr., 97 295 3) Jarosova et al. (2019), Metabolism of Stilbenoids by Human Faecal Microbiota; Molecules, 24 E1155 4) Radco et al. (2013), Semi-preparative isolation of dihydroresveratrol-3-O-ß-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 930 54 5) Oode et al. (2014), Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells; Eur. J. Med. Chem., 87 862 6) Faragher et al. (2011), Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts; Age (Dordr.), 33 555
-20°C
TARGET: Protein deacetylase; Antioxidant -- PATHWAY: Chromatin; Redox; Fatty acid metabolism; Senescence -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Ageing