Apigenin
Protein kinase inhibitor / Apigenin is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of cellular proliferation via G2/M cell cycle arrest3,5, reduction of HIF-1 and VEGF expression6, and inhibition of nitric oxide and PGE2 synthesis7.
Biochemicals & reagents
520-36-5
4′,5,7-Trihydroxyflavone
1) Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 / 2) Zhao et al. (2011) Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90 Mol. Cancer 10 10 / 3) Yin et al. (2001) Apigenin inhibits growth and induces G2/M arrest by modulating cyclinCDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Research 21 413 / 4) Si et al. (2009) Mechanism of CYP2C9 inhibition by flavones and flavonols Drug Metabolism and Disposition 37 629 / 5) Sato et al. (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells Biochem. Biophys. Res. Commun. 204 578 / 6) Fang et al. (2007) Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression Carcinogenesis 28, 858 / 7) Raso et al. (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 68 921
RT
TARGET: Kinase; Antioxidant -- PATHWAY: Redox; Proliferation -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Infectious disease