Rosmarinic acid
Antioxidant / Displays radical scavenging1, anti-inflammatory2 and amyloid- aggregation inhibition activities3. Acts as an agonist at GPR354.
Biochemicals & reagents
20283-92-5
1) Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoids by means of LC-DAD-SPE-NMR; J. Nat. Prod., 68 168 2) Sahu et al. (1999), Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b; Biochem. Pharmacol, 57 1439 3) Ono et al. (2012), Phenolic compounds prevented amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding; J. Biol. Chem., 287 14631 4) Deng et al. (2012), Multiple tyrosine metabolites are GPR35 agonists; Sci. Rep., 2 373
RT
TARGET: GPCR; Antioxidant -- PATHWAY: Redox; Glycation -- RESEARCH AREA: Neuroscience; Oxidative stress -- DISEASE AREA: Inflammation; NeurodegenerationDiabetes