Decylubiquinone
MPTP inhibitor / Inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5 μM via inhibition of cytochrome c release.2 Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function.3 Substrate for various quinone oxidoreductases.4,5
Biochemicals & reagents
55486-00-5
1) Fontaine et al. (1998), A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore; J. Biol. Chem., 273 25734 2) Karpinich et al. (2002), The course of Etoposide-Induced Apoptosis from Damage to DNA and p53 Activation to Mitochodrial Release of Cytochrome c; J. Biol. Chem., 277 16547 3) Pinho et al. (2013) How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs; Br. J. Pharmacol., 169 1072 4) Kunow et al. (1994) F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters; Eur. J. Biochem., 223 503 5) Zickermann et al (1998) Analysis of the pathogenic human mitochondria mutation ND1/3460 and mutations of strictly conserved residues in it’s vicinity, using the bacterium Paracoccis denitrificans; Biochemistry, 37 11792
-20°C
TARGET: Cytochrome/MDR; Antioxidant -- PATHWAY: Mitochondrial function; Apoptosis inhibitor; Cholesterol metabolism -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Heart disease; Hypertension