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L-Ergothioneine

Supplier:
Catalogue number:
10-3012-01
Size:
20 mg
Product is available in:
  • USA
  • Canada
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Antioxidant - endogenous / Naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM1. Rescues PC12 cells from β-amyloid-induced apoptotic cell death2. Protects against cisplatin-induced neuronal injury and enhances cognition in a mouse model3. Interferes with endothelial cell senescence4.

Product Type:

Biochemicals & reagents

CAS Number:

497-30-3

Alternative Names:

2-Mercaptohistidine betaine; NSC-7175

Reference:

1) Cheah and Halliwell (2012), Ergothioneine: antioxidant potential, physiological function and role in disease; Biochim. Biophys. Acta, 1822 784 2) Jang et al. (2004), Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death; Free Radic. Biol. Med., 36 288 3) Song et al. (2010), Ergothioneine protects against neuronal injury induced by cisplatin both invitro and in vivo; Food Chem. Toxicol. 48 3492 4) D’Onofrio et al. (2016), Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6; Free Radic. Biol. Med., 96 211

Storage Temperature:

-20°C

Additional Information:

TARGET: Antioxidant; Antibiotic -- PATHWAY: Redox; Apoptosis inhibitor; Senescence -- RESEARCH AREA: Neuroscience; Cell death; Oxidative stress -- DISEASE AREA: Neurodegeneration; Infectious diseaseAgeing