L-Ergothioneine
Antioxidant - endogenous / Naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM1. Rescues PC12 cells from β-amyloid-induced apoptotic cell death2. Protects against cisplatin-induced neuronal injury and enhances cognition in a mouse model3. Interferes with endothelial cell senescence4.
Biochemicals & reagents
497-30-3
2-Mercaptohistidine betaine; NSC-7175
1) Cheah and Halliwell (2012), Ergothioneine: antioxidant potential, physiological function and role in disease; Biochim. Biophys. Acta, 1822 784 2) Jang et al. (2004), Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death; Free Radic. Biol. Med., 36 288 3) Song et al. (2010), Ergothioneine protects against neuronal injury induced by cisplatin both invitro and in vivo; Food Chem. Toxicol. 48 3492 4) D’Onofrio et al. (2016), Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6; Free Radic. Biol. Med., 96 211
-20°C
TARGET: Antioxidant; Antibiotic -- PATHWAY: Redox; Apoptosis inhibitor; Senescence -- RESEARCH AREA: Neuroscience; Cell death; Oxidative stress -- DISEASE AREA: Neurodegeneration; Infectious diseaseAgeing