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Bupropion HCl

Supplier:
Catalogue number:
10-2462-02
Size:
250 mg
Product is available in:
  • USA
  • Canada
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Monoamine transporter inhibitor / Clinically useful antidepressant that inhibits monoamine transporters DAT, NET, and SERT (Kis for dopamine uptake = 2.8, 1.4, 45 µM).1 Also acts as a noncompetitive antagonist at nicotinic acetylcholine receptors (AChRs).2 At higher concentrations (50 µM), stimulates pro-inflammatory cytokines and TLR2/TLR4 and JAK2/STAT3 in human peripheral blood mononuclear cells (PBMCs).3

Product Type:

Biochemicals & reagents

CAS Number:

31677-93-7

Reference:

Urra et al. (2014), Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity; PLoS One, 9 e112834 Fryer and Lukas (1999), Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine; J. Pharmacol. Exp. Ther., 288 88 Karimollah et al. (2021), Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3; Inflammopharmacology, 29 1101

Storage Temperature:

-20°C

Additional Information:

TARGET: Dopamine; Acetylcholinesterase/Butyrylcholinesterase -- PATHWAY: Cytokine; TLR signaling; JAK/STAT; ACh (Acetylcholine) signaling -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Mood disorders; AddictionInflammation