Bupropion HCl
Monoamine transporter inhibitor / Clinically useful antidepressant that inhibits monoamine transporters DAT, NET, and SERT (Kis for dopamine uptake = 2.8, 1.4, 45 µM).1 Also acts as a noncompetitive antagonist at nicotinic acetylcholine receptors (AChRs).2 At higher concentrations (50 µM), stimulates pro-inflammatory cytokines and TLR2/TLR4 and JAK2/STAT3 in human peripheral blood mononuclear cells (PBMCs).3
Biochemicals & reagents
31677-93-7
Urra et al. (2014), Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity; PLoS One, 9 e112834 Fryer and Lukas (1999), Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine; J. Pharmacol. Exp. Ther., 288 88 Karimollah et al. (2021), Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3; Inflammopharmacology, 29 1101
-20°C
TARGET: Dopamine; Acetylcholinesterase/Butyrylcholinesterase -- PATHWAY: Cytokine; TLR signaling; JAK/STAT; ACh (Acetylcholine) signaling -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Mood disorders; AddictionInflammation