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Punicalagin

Supplier:
Catalogue number:
10-4583-02
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Anti-inflammatory / antioxidant / anti-tumor agent / Punicalagin is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2 It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3 Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4

Product Type:

Biochemicals & reagents

CAS Number:

65995-63-3

Reference:

1) Seeram et al. (2005), In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J.Nutr.Biochem.16 360 2) Adams et al. (2006), Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J.Agric.Food Chem. 54 980 3) Zhong et al. (2015), Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem.Biophys.Res.Commun. 467 179 4) Cao et al. (2015), Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci.Rep. 5 14014

Storage Temperature:

-20°C

Additional Information:

TARGET: Antioxidant; Antibiotic -- PATHWAY: Redox; AMPK pathway -- RESEARCH AREA: Cellular stress -- DISEASE AREA: Diabetes; CancerObesity; Infectious disease