Geldanamycin-FITC
HSP90 fluorescent probe / A novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors2,3. May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy4.
Biochemicals & reagents
Unknown
GDA-C6-FITC
1) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975 2) Kim et al. (2004), Development of a fluorescent polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375 3) Austin et al. (2012), Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen., 17 868 4) Gooljarsingh et al. (2006), A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues; Proc. Natl. Acad. Sci. USA, 103 7625
-20°C
TARGET: HSP (Heat shock protein); Antibiotic; Substrate / Probe -- PATHWAY: Autophagy -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death; Cellular stress -- DISEASE AREA: Cancer; Infectious disease