7-Aminoactinomycin D
Fluorescent DNA Probe / Fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry.1,2 Capable of identifying populations representing live, apoptotic, and late apoptotic/dead cells in a quick, simple, reproducible, cost-effective fashion.3,4 Inhibitor of DNA-primed RNA polymerase and DNA polymerase.5
Biochemicals & reagents
7240-37-1
1) Telieps et al. (2013) Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur.J.Immunol. 43 1499 2) Schmid et al. (2007) Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat.Protoc. 2 187 3) Toba et al. (2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10 4) Lecoeur et al. (1997) Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J.Immunol.Methods 209 111 5) Su et al. (1996) Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J.Immunol. 156 4198
-20°C / Protect from light
TARGET: DNA; Antibiotic; Substrate / Probe -- PATHWAY: Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease