Porcn inhibitor: Wnt/Beta-catenin pathway inhibitor / IWP-4 is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=25 nM) by inhibition of the O-palmitoyltransferase Porcn.1 Induces cardiomyocyte differentiation from human pluripotent stem cells.2,3 An important tool for probing the involvement of the Wnt pathway in physiological processes.4 Cell permeable.
Biochemicals & reagents
686772-17-8
1 Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nat. Chem. Biol. 5 100 2 Lian et al. (2012), Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling; Proc. Natl. Acad. Sci. USA 109 1848 3 Muneer et al. (2023), Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo; World J. Stem Cells 15 821 4 Zhao et al. (2022), LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression; J. Bone Metab. 40 66
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TARGET: Acyltransferase; Kinase; Transcription factor -- PATHWAY: Wnt; Lipid signaling -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer; Heart disease