R-59022
DAG Kinase inhibitor / R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4
Biochemicals & reagents
93076-89-2
Diacylglycerol kinase inhibitor i
1) de Chaffoy de Courcelles et al. (1985), R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet; J. Biol. Chem., 260 15762 2) Takita et al. (2011), Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15; Arch. Biochem. Biphys., 509 197 3) Martinez et al. (2013), Diacylglycerol kinase inhibitor R59022 atteniates conjugated linoleic acid-mediated inflammation in human adipocytes; J. Lipid Res., 54 662 4) Stewart et al. (2019), A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells; Viruses, 11 206
-20°C
TARGET: Kinase; Monoamine receptor; Serotonin -- PATHWAY: Autophagy; Apoptosis inducer; Redox; Glucose metabolism; Calcium signaling; PKC -- RESEARCH AREA: Cell death; Neuroscience; Immunology -- DISEASE AREA: Obesity; InflammationCancer