SKF525A ∙ HCl
Cytochrome P450 inhibitor / SKF-525A is a commonly used non-selective Cytochrome P450 inhibitor.1 It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the desensitized state of muscle AChR4. SKF-525A also inhibits glibenclamide-sensitive K+ channels.5
Biochemicals & reagents
62-68-0
Proadifen
1) Franklin and Hathaway (2008) 2-Diethylaminoethyl-2,2-diphenylvalerate-HCL )SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol Drug Metab.Dispos. 36 2539 2) Suarez-Kurtz and Bianchi (1970) Sites of action of SKF-525A in nerve and muscle J.Pharmacol.Exp.Ther. 172 33 3) Spitzmaul et al. (2009) The local anesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms; Br.J.Pharmacol. 157 804 4) Prince and Sine et al. (1999) Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models; J.Biol.Chem. 274 19623 5) Sakust and Yoneda (1994) Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes; Eur.J.Pharmacol. 252 117
-20°C
TARGET: Cytochrome/MDR; Ion channel; NOS (Nitric oxide synthase) -- PATHWAY: Cation channel; Coagulation; Cytokine; ACh (Acetylcholine) signaling -- RESEARCH AREA: Neuroscience; Oxidative Stress -- DISEASE AREA: Pain; InflammationCancer