Phenylhexyl isothiocyanate
Chemopreventive; HDAC inhibitor; p53 reactivator / Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC was the most potent in a series of synthetic arylalkyl isothiocyanates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model.2 It was also found to induce apoptosis and inhibit leukemia cell growth in vivo3 and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent4. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.5
Biochemicals & reagents
133920-06-6
PHITC; PHI
1 Srivastava et al. (2003), Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo; Carcinogenesis, 24 1665 2 Morse et al. (1991), Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice; Cancer Res., 51 1846 3 Lu et al. (2006), The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo; Oncol. Rep., 16 1363 4 Lu et al. (2008), Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways; Haematol. Oncol., 1 6 5 Zou et al. (2019), Phenylhexyl isothiocyanate suppresses cell proliferation and promotes apoptosis via repairing mutant P53 in human myeloid leukemia M2 cells; Oncol. Lett., 18 3358
-20°C
TARGET: Acetyltransferase; DNA methyltransferase; Protein methyltransferase -- PATHWAY: PI3K; AKT; p53; Chromatin -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer