Terguride
Dopamine D2 agonist / A semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys1. Partial agonist at recruitment of -arrestin2 to the D2 receptor2. Ameliorates monocrotaline-induced pulmonary hypertension in rats3.
Biochemicals & reagents
37686-84-3
S(+)-Terguride
1) Akai et al. (1993), Effects pf terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507 2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215 3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104
RT
TARGET: Monoamine receptor; Dopamine; GPCR -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration; Hypertension